International Company «ASINEX»
Москва, www.asinex.com
Химическое производство, удобрения... Показать еще
Head of the American project "HCV", search for antiviral drugs against the "Hepatitis C" pharmaceutical company "Progenics"
Head of the American project "HCV", search for antiviral drugs against the "Hepatitis C" pharmaceutical company "Progenics" (www.progenics.com), a project FTE (Full Time Equivalent) in the laboratory of organic synthesis International Company «ASINEX» Moscow (www.asinex.com).
The international company provides services ASINEX in fine organic synthesis of chemical compounds and medicinal-governmental search of candidates for the leading international pharmaceutical corporations, radios and biotech firms. Since 1994, ASINEX is a recognized leader in branch of create collections drugs substances that are used by pharmaceutical companies as sources of compounds hits. Since 1998, an even greater priority for the company's service was chemistry. Since 2001, ASINEX operates its own department of biological screening. At the disposal of chemists and biologists of the latest equipment, library subscriptions to leading journals, the possibility of publications and participation in international conferences. ASINEX sends to the young graduate employees by offering advanced facilities and scientific management for dissertation research.
Responsibilities:
Research and development on a given topic as a performer of responsible and independent implementation of the study of the complex, experiments and observations
Selection and management of laboratory staff
Design analysis of bioactive compounds
Organization Development Lab ready to ski the potential biological active compounds
Participation in the preparation of scaling methods developed bio-active compounds
Development synthetic strategies of transformation, isolation (extraction, TLC, column chromatography, high performance column chromatography, crystallization, sublimation)
The ability to identify the parameters of 1H and 13C NMR, mass spectrometry, IR, UV, Visible spectroscopy, X-ray crystallography and element analysis
Experience the lab equipment (including HPLC, TLC)
Solving problems of translation oily compounds in solid state is
Testing (test) samples of raw materials, auxiliary materials, semi finished and finished products to the regulatory documents, as well as the additional demands made by spec-specific production of concrete production
Implementation of the analyzes of samples to test the stability
Analysis of the unique, patent search
Order the necessary reagents and equipment for an experimental pa-bots
Collect, process, analyze and summarize the results of experiments and observations in the light of responsible and foreign data on the study
Participate in the development of plans and teaching programs, research, recommendations for the use of their results, as well as their practical implementation
Theoretical and experimental investigation of new compounds and obtaining LF finished medicinal substances
Participation in exhibitions and conferences
Design of experimental results and research
Making reporting documentation for end products developed by you: specification, explanatory notes, tables, stability, the laboratory regulations, etc.
Implementation of inspection and testing of methods of analysis
Knowledge of safety and fire safety in accordance with the requirements of their jobs
Good skills in written and oral communication, English, intermediate level
01.2007-12.2007
Deputy leader of the American farm project company "Progen-ics". Head of the laboratory. International Company «ASINEX» Moscow.
Responsibilities:
Working with records, writing reports, database operations MDL CrossFire, planning and research multistep organic syntheses involving analytical methods (IR, UV, GC, and HPLC, MS, NMR) for the proof of the structure.
Search for an antiviral drug against the "Hepatitis C".
Planning, equipping, and negotiations with suppliers of equipment for the construction of the laboratory of organic synthesis, Moscow, Russia.
The scientific approach, design of experiments, creativity, innovation-tion management, analytical skills, a systematic approach, high trainability.
Participation in international projects pharmaceutical companies: Progenics (USA), Astelas (Sweden), Takeda (Japan), Asinex (into project - Russia).
The planning, synthesis and connections to bring the commercial product, giving the region: GPCR, ion channel, kinase, antiviral, protivoyazven-tion, and other analgesic activity.
08.2005-12.2006
Synthetic chemist (organic synthesis), scientific research, the International Company «ASINEX» Moscow.
Responsibilities:
Working with multi-step organic synthesis, preparative chromatography column from the micro to macroscopic (on a scale of 1 g and more than 200g)
Skills of modern methods of organic synthesis
Ability to work independently, creative approach to solving the problems of synthetic-profit
Participation in the drafting of technological modes of application of reagents
Techno-economic evaluation of the use of reagents
Participation in the preparation of proposals optimize the use of reagents of consumers, improve dosing, storage of reagents
Holding the control input of raw materials and finished products
Preparation of equipment and support materials for use in laboratories
Quality control of raw materials and products at all stages of the techno-logical process
Maintain accounting records
Molecular design of organic molecules, combinatorial synthesis, synthesis of biologically active bildin blocks, synthons, chiral substrates and derivatives, the chemistry of carbonyl, amide, 1,3,5-triazine, sul famidnyh azo-, thia-, oxygen-5 -, 6 - and 7 membered heterocyclic-profit polyfunctional systems. The reaction of heterocyclization, funktsiolizatsii, cross - a combination of (Suzuki), isomerization to Ru - catalysts (metathesis).